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Updated: Feb 11, 2026

Enrichment of Bacterial Lipoproteins and Preparation of N-terminal Lipopeptides for Structural Determination by Mass Spectrometry
Published on: May 21, 2018
Ypaoamides B and C, Linear Lipopeptides from an Okeania sp. Marine Cyanobacterium
Kosuke Sueyoshi1, Miki Yamada1, Aki Yamano1
1Faculty of Education , University of the Ryukyus , 1 Senbaru , Nishihara , Okinawa 903-0213 , Japan.
Abstract:
Two new pyrrolinone-containing lipopeptides, ypaoamides B (1) and C (2), were isolated from an Okeania sp. marine cyanobacterium collected in Okinawa. Their structures were determined by spectroscopic analysis and Marfey's analysis of acid hydrolysates. Ypaoamides B (1) and C (2) stimulated glucose uptake in cultured rat L6 myotubes. In particular, ypaoamide B (1) showed potent activity and activated AMP-activated protein kinase.
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