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Updated: Feb 11, 2026

Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease
Published on: May 13, 2010
Development of DNA aptamers targeting low-molecular-weight amyloid-β peptide aggregates in vitro
Madhuri Chakravarthy1, Hadi AlShamaileh, He Huang
1Centre for Comparative Genomics, Murdoch University, Perth, 6150, Australia. R.Veedu@murdoch.edu.au.
Abstract:
We have developed a novel functional nucleic acid aptamer to amyloid-β peptide 1-40 (Aβ1-40) and investigated its potential to detect Aβ peptide fragments in neuropathologically confirmed Alzheimer brain hippocampus tissues samples. Our results demonstrate that the aptamer candidate RNV95 could detect tetrameric/pentameric low-molecular-weight Aβ aggregates in autopsy hippocampal tissue from two neuropathologically confirmed Alzheimer disease cases. Although these are preliminary observations, detailed investigations are under way. This is the first demonstration of aptamer-Aβ binding in Alzheimer brain tissues.
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