Accurate IVIM model-based liver lesion characterisation can be achieved with only three b-value DWI

The objective of this study was to evaluate a simplified intravoxel incoherent motion (IVIM) approach of diffusion-weighted imaging (DWI) with four b-values for liver lesion characterisation at 1.5 T.

DWI data from a respiratory-gated MRI sequence with b = 0, 50, 250, 800 s/mm² were retrospectively analysed in 173 lesions and 40 healthy livers. The apparent diffusion coefficient ADC = ADC(0,800) and IVIM-based parameters D₁' = ADC(50,800), D₂' =ADC(250,800), f₁', f₂', D*', ADC_low = ADC(0,50), and ADC_diff=ADC_low-D₂' were calculated voxel-wise without fitting procedures. Differences between lesion groups were investigated.

Focal nodular hyperplasias were best discriminated from all other lesions by f₁' with an area under the curve (AUC) of 0.989. Haemangiomas were best discriminated by D₁' (AUC of 0.994). For discrimination between malignant and benign lesions, ADC(0,800) and D₁' were best suited (AUC of 0.915 and 0.858, respectively). Discriminatory power was further increased by using a combination of D₁' and f₁'.

IVIM parameters D and f approximated from three b-values provided more discriminatory power between liver lesions than ADC determined from two b-values. The use of b = 0, 50, 800 s/mm² was superior to that of b = 0, 250, 800 s/mm². The acquisition of four instead of three b-values has no further benefit for lesion characterisation.

• Diffusion and perfusion characteristics are assessable with only three b-values. • Association of b = 0, 50, 800 s/mm²is superior to b = 0, 250, 800 s/mm². • A fourth acquired b-value has no benefit for differential diagnosis. • For liver lesion characterisation, simplified IVIM analysis is superior to ADC determination. • Simplified IVIM approach guarantees numerically stable, voxel-wise results and short acquisition times.