Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Esophageal Varices-I: Introduction01:24

Esophageal Varices-I: Introduction

1.5K
Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
1.5K
Bleeding in Fresh Concrete01:22

Bleeding in Fresh Concrete

616
Bleeding in fresh concrete occurs when water from the mix rises to the surface. This happens because the mix's solid components fail to retain all the water as they settle, leading to separation where water collects at the top. The severity of bleeding can be measured by assessing the total settlement or by noting the decrease in height per unit height of concrete.
Bleeding can cause several issues in the concrete structure. Sometimes, the rising water gets trapped beneath large aggregate...
616
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

605
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
605
Anatomy of the Gastrointestinal System01:26

Anatomy of the Gastrointestinal System

2.9K
The human digestive system is an intricate and essential network for nutrient absorption and waste elimination. It encompasses the gastrointestinal (GI) tract and several accessory organs.
Here's a detailed walkthrough of this complex system:
2.9K
Arteries of the Upper Limbs01:12

Arteries of the Upper Limbs

2.5K
The subclavian artery transitions into the axillary artery as it exits the chest and enters the axillary region. This artery is critical for supplying blood to the shoulder area, including the head of the humerus, through the humeral circumflex arteries. As the vessel continues into the upper arm or brachium, it becomes the brachial artery. This artery plays a key role in vascularizing the brachial region and bifurcates at the elbow into several branches. These branches include the deep...
2.5K
Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

1.3K
Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-Term Colorectal Cancer Incidence After Adenoma and Serrated Polyp Removal: Results From the Colonprev Trial.

United European gastroenterology journal·2026
Same author

Colonoscopy versus biennial FIT screening: a post hoc sustained-strategy analysis of the COLONPREV Trial.

Gut·2026
Same author

Waiting for cholecystectomy: determinants of prioritization for delayed cholecystectomy in a universal public healthcare system-post hoc analysis of RELAPSTONE cohort (WAIT-CHOL study).

BJS open·2026
Same author

Validation of Predictive Equations for Estimating Lean Soft Tissue and Fat-Free Mass in Class II-V Obesity: A Multicenter Observational Study with Implications for Bariatric Surgery Monitoring.

Journal of obesity & metabolic syndrome·2026
Same author

Editorial: Advancing gastrointestinal disease diagnosis with interpretable AI and edge computing for enhanced patient care.

Frontiers in medicine·2026
Same author

Higher Doses of Bismuth and Antibiotics Do Not Improve Helicobacter pylori Treatment Effectiveness: Results From the European Registry on Helicobacter pylori Management.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2026
Same journal

Accidental hypothermia.

Nature reviews. Disease primers·2026
Same journal

Accidental hypothermia.

Nature reviews. Disease primers·2026
Same journal

Primary aldosteronism.

Nature reviews. Disease primers·2026
Same journal

Primary aldosteronism.

Nature reviews. Disease primers·2026
Same journal

Buruli ulcer in Africa: between innovation and pragmatism.

Nature reviews. Disease primers·2026
Same journal

Author Correction: Atopic dermatitis.

Nature reviews. Disease primers·2026
See all related articles

Related Experiment Video

Updated: Feb 11, 2026

Underwater Endoscopic Injection Sclerotherapy for Gastroesophageal Varices
02:14

Underwater Endoscopic Injection Sclerotherapy for Gastroesophageal Varices

Published on: August 1, 2025

1.6K

Non-variceal upper gastrointestinal bleeding.

Angel Lanas1,2, Jean-Marc Dumonceau3, Richard H Hunt4

  • 1Service of Digestive Diseases, University Clinic Hospital Lozano Blesa, University of Zaragoza, IIS Aragón, Zaragoza, Spain.

Nature Reviews. Disease Primers
|April 20, 2018
PubMed
Summary
This summary is machine-generated.

Non-variceal upper gastrointestinal bleeding (NVUGIB) is a common emergency, often caused by ulcers. Early endoscopy and proton pump inhibitors (PPIs) are key treatments, balancing bleeding risks with cardiovascular health.

More Related Videos

Endoscopic Injection Sclerotherapy Assisted by Cyanoacrylate and Clips for Gastroesophageal Varices
04:09

Endoscopic Injection Sclerotherapy Assisted by Cyanoacrylate and Clips for Gastroesophageal Varices

Published on: June 13, 2025

1.2K
Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension
04:00

Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension

Published on: November 15, 2024

813

Related Experiment Videos

Last Updated: Feb 11, 2026

Underwater Endoscopic Injection Sclerotherapy for Gastroesophageal Varices
02:14

Underwater Endoscopic Injection Sclerotherapy for Gastroesophageal Varices

Published on: August 1, 2025

1.6K
Endoscopic Injection Sclerotherapy Assisted by Cyanoacrylate and Clips for Gastroesophageal Varices
04:09

Endoscopic Injection Sclerotherapy Assisted by Cyanoacrylate and Clips for Gastroesophageal Varices

Published on: June 13, 2025

1.2K
Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension
04:00

Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension

Published on: November 15, 2024

813

Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Clinical Management

Background:

  • Non-variceal upper gastrointestinal bleeding (NVUGIB) originates in the esophagus, stomach, or duodenum.
  • Peptic ulcers, linked to H. pylori or NSAID/aspirin use, are the primary cause of NVUGIB.
  • Despite decreasing incidence and mortality, NVUGIB remains a significant clinical issue with a 1-5% mortality rate.

Purpose of the Study:

  • To outline the current understanding and management strategies for NVUGIB.
  • To emphasize the importance of early endoscopic intervention and acid suppression.
  • To address the complexities of managing NVUGIB in aging populations on antiplatelet/anticoagulant therapy.

Main Methods:

  • Initial resuscitation and assessment are followed by early diagnostic and therapeutic endoscopy (within 24 hours).
  • Intragastric pH control using proton pump inhibitors (PPIs) is a cornerstone of treatment.
  • Risk factor identification and preventive strategies, including PPIs and H. pylori eradication, are crucial.

Main Results:

  • Advances in prevention and management have reduced NVUGIB incidence and mortality over two decades.
  • Balancing gastrointestinal bleeding risk against adverse cardiovascular events is critical in elderly patients.
  • Proton pump inhibitors (PPIs) and selective COX-2 NSAIDs are recommended for high-risk patients needing NSAIDs and/or low-dose aspirin (LDA).

Conclusions:

  • Early endoscopic intervention and intragastric pH control with PPIs are fundamental to NVUGIB management.
  • Preventive measures, including PPIs and H. pylori eradication, are vital for at-risk individuals.
  • Careful consideration of patient-specific risks is necessary for optimal NVUGIB treatment, especially in older adults.