An unusual cutaneous reaction secondary to allopurinol

A 60-year-old man presented with erythematous papules and plaques on his body as well as a violaceous indurated nodule on his face. A cutaneous drug reaction secondary to allopurinol was considered. Examination of biopsy specimens revealed a dense lymphocytic infiltrate of the skin as is seen in lymphocytoma cutis. The lesions cleared promptly after use of allopurinol was discontinued. A literature review showed that an eruption of this kind, including a nodule on the face that histologically simulated a lymphocytic infiltrate of the skin, has not yet been reported secondary to allopurinol.