Related Experiment Video
Updated: Feb 11, 2026

A High-content Assay for Monitoring AMPA Receptor Trafficking
Published on: January 28, 2019
[MOBILITY OF AMPA SUBTYPE GLUTAMATE RECEPTOR AS A KEY FACTOR OF EXPRESSION AND MAINTENANCE OF SYNAPTIC POTENTIATION]
Abstract:
A time dynamic of LTP development in the first minutes after high frequency stimulation has been investigated by using a cell model of synaptic potentiation. An experimental assessment of dependence of potentiation and maintenance of a stable level of synaptic transmission in the CA1 area of mice hippocampus on the intracellular transport has been made with brefeldin A (the blocker of transport vesicle forming). The integrative activity of the systems, ensuring the delivery of glutamate receptors to the dendrite spines in amounts and in time intervals necessary for fast changing and long maintenance of transmission efficiency is discussing.
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