Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein and Protein Structure02:15

Protein and Protein Structure

88.9K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
88.9K
Protein Complex Assembly02:41

Protein Complex Assembly

16.9K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
16.9K
Protein Complex Assembly02:41

Protein Complex Assembly

2.6K
2.6K
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

2.9K
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
2.9K
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

2.1K
2.1K
Structural Protein Function01:56

Structural Protein Function

30.0K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
30.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic Value of Cardiac Biomarkers in Acute Myocardial Infarction: A Systematic Review and Meta-Analysis.

Cureus·2026
Same author

Comparative effectiveness of figure-of-eight suture and manual compression for femoral venous hemostasis after atrial fibrillation ablation: A grade assessed meta-analysis.

Journal of thrombosis and thrombolysis·2026
Same author

A Molecular Diagnostic Platform Devised from Supramolecular Gold-Oligo NanoNet Assembly for Differentiating RhD Genotypes Among Transfusion-Dependent Patients.

ACS applied bio materials·2026
Same author

Dual Role of Small Noncoding RNA and Hfq in Bacterial DNA Compaction: A New Perspective on Nucleoid Architecture.

ACS omega·2026
Same author

Self-assembly driven superstructures in nanotechnology: emergent phenomena, characterization and applications.

Nanotechnology·2026
Same author

Resolving Complex Multiscale Structure of Magneto- and Electroactive Polymer Composites With an Ionic Liquid.

Advanced materials (Deerfield Beach, Fla.)·2026

Related Experiment Video

Updated: Feb 11, 2026

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis
07:31

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis

Published on: July 16, 2020

6.6K

Structure and Interaction of Nanoparticle-Protein Complexes.

Sugam Kumar1, Indresh Yadav1,2, Vinod Kumar Aswal1,2

  • 1Solid State Physics Division, Bhabha Atomic Research Centre, Mumbai 400 085 , India.

Langmuir : the ACS Journal of Surfaces and Colloids
|April 20, 2018
PubMed
Summary

Protein-nanoparticle interactions are key for nanobiotechnology. Different proteins like lysozyme and BSA exhibit unique adsorption on silica nanoparticles, leading to phase changes and altered nanoparticle attraction, crucial for applications.

More Related Videos

Analyzing Large Protein Complexes by Structural Mass Spectrometry
15:35

Analyzing Large Protein Complexes by Structural Mass Spectrometry

Published on: June 19, 2010

24.9K
Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry
07:33

Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry

Published on: October 15, 2018

15.0K

Related Experiment Videos

Last Updated: Feb 11, 2026

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis
07:31

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis

Published on: July 16, 2020

6.6K
Analyzing Large Protein Complexes by Structural Mass Spectrometry
15:35

Analyzing Large Protein Complexes by Structural Mass Spectrometry

Published on: June 19, 2010

24.9K
Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry
07:33

Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry

Published on: October 15, 2018

15.0K

Area of Science:

  • Nanotechnology
  • Biotechnology
  • Materials Science

Background:

  • Nanoparticle-protein complexes merge nanoscale properties with protein functions.
  • These complexes are vital for nanobiotechnology, including nanomedicine, drug delivery, and biosensors.
  • Understanding nanoparticle-protein interactions is essential for developing these applications.

Purpose of the Study:

  • To explore driving interactions in nanoparticle-protein systems.
  • To investigate the resultant structures and phase behavior.
  • To present recent studies on anionic colloidal silica nanoparticles with lysozyme and bovine serum albumin (BSA).

Main Methods:

  • Investigated anionic colloidal silica nanoparticles as a model system.
  • Studied the adsorption behavior of lysozyme and bovine serum albumin (BSA) on nanoparticles.
  • Analyzed phase transformation and nanoparticle interactions under varying physiochemical parameters.

Main Results:

  • Proteins showed distinct adsorption behaviors on nanoparticles.
  • Both proteins induced a phase transformation from one to two phases.
  • Protein presence altered nanoparticle attraction, inducing short-range (lysozyme) and long-range (BSA) forces.
  • Phase behavior depended on nanoparticle size, ionic strength, and pH.

Conclusions:

  • Protein adsorption significantly influences nanoparticle interactions and system phase behavior.
  • The findings provide insights into controlling nanoparticle-protein complex formation for nanobiotechnology.
  • Understanding these interactions is critical for designing advanced nanomaterials and applications.