Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Separable Differential Equations01:20

Separable Differential Equations

109
A separable differential equation is a type of first-order differential equation where the derivative dy/dx can be expressed as a product of two functions: one that depends only on x and another that depends only on y. This allows for the rearrangement of the equation so that all terms involving y are on one side, and all terms involving x are on the other. This process, known as the separation of variables, simplifies the process of solving the equation by enabling the integration of both...
109
Differential Form of Maxwell's Equations01:17

Differential Form of Maxwell's Equations

1.3K
James Clerk Maxwell (1831–1879) was one of the significant contributors to physics in the nineteenth century. He is probably best known for having combined existing knowledge of the laws of electricity and the laws of magnetism with his insights to form a complete overarching electromagnetic theory, represented by Maxwell's equations. The four basic laws of electricity and magnetism were discovered experimentally through the work of physicists such as Oersted, Coulomb, Gauss, and...
1.3K
Abnormal Proliferation02:23

Abnormal Proliferation

5.3K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.3K
Structural Protein Function01:56

Structural Protein Function

30.0K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
30.0K
Introduction to Urinary System01:13

Introduction to Urinary System

9.3K
The urinary system consists of two kidneys, two ureters, the urinary bladder, and the urethra.
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
9.3K
Urinary Bladder01:23

Urinary Bladder

3.5K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Denosumab for osteoporosis in older adults in long-term care: A randomized trial.

Journal of the American Geriatrics Society·2024
Same author

Subsidized Versus Unsubsidized Senior Housing Communities in PA: A Window on Variation in Health, Function, and Access to Services in Old Age.

Gerontology & geriatric medicine·2024
Same author

A molecular index for biological age identified from the metabolome and senescence-associated secretome in humans.

Aging cell·2024
Same author

Impact of sleep on chronobiology of micturition among healthy older adults.

American journal of physiology. Renal physiology·2023
Same author

Current Issues in Neuroimaging Research Focused on Urge Urinary Incontinence.

The Journal of urology·2023
Same author

Speaking the Same Language: Team Science Approaches in Aging Research for Integrating Basic and Translational Science With Clinical Practice.

Innovation in aging·2023

Related Experiment Video

Updated: Feb 11, 2026

Mouse Mammary Epithelial Cells form Mammospheres During Lactogenic Differentiation
04:51

Mouse Mammary Epithelial Cells form Mammospheres During Lactogenic Differentiation

Published on: October 6, 2009

14.7K

Do brain structural abnormalities differentiate separate forms of urgency urinary incontinence?

Becky D Clarkson1, Derek Griffiths1, Neil M Resnick1

  • 1Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

Neurourology and Urodynamics
|April 20, 2018
PubMed
Summary

Urgency urinary incontinence (UUI) in seniors is linked to white-matter damage affecting bladder control pathways. Biofeedback-assisted pelvic floor muscle training (BFB) may help some patients, but effectiveness varies based on brain abnormalities.

Keywords:
diffusion tensor imagingmagnetic resonance imagingvoxel-based morphometrywhite matter hyperintensities

More Related Videos

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
05:25

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Published on: August 14, 2019

20.2K
Analysis of β-Amyloid-induced Abnormalities on Fibrin Clot Structure by Spectroscopy and Scanning Electron Microscopy
06:27

Analysis of β-Amyloid-induced Abnormalities on Fibrin Clot Structure by Spectroscopy and Scanning Electron Microscopy

Published on: November 30, 2018

9.8K

Related Experiment Videos

Last Updated: Feb 11, 2026

Mouse Mammary Epithelial Cells form Mammospheres During Lactogenic Differentiation
04:51

Mouse Mammary Epithelial Cells form Mammospheres During Lactogenic Differentiation

Published on: October 6, 2009

14.7K
Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
05:25

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Published on: August 14, 2019

20.2K
Analysis of β-Amyloid-induced Abnormalities on Fibrin Clot Structure by Spectroscopy and Scanning Electron Microscopy
06:27

Analysis of β-Amyloid-induced Abnormalities on Fibrin Clot Structure by Spectroscopy and Scanning Electron Microscopy

Published on: November 30, 2018

9.8K

Area of Science:

  • Neuroscience
  • Geriatrics
  • Urology

Background:

  • Urgency urinary incontinence (UUI) significantly impacts seniors' quality of life.
  • The underlying neurological mechanisms and therapeutic targets for UUI remain largely unknown.
  • Previous functional MRI studies indicated functional brain differences in UUI patients.

Purpose of the Study:

  • To identify structural brain abnormalities associated with UUI.
  • To investigate brain differences between UUI patients and controls.
  • To explore structural correlates of therapy response in UUI patients.

Main Methods:

  • Secondary analysis of a biofeedback-assisted pelvic floor muscle training (BFB) trial.
  • Inclusion of 60 women (>60 yrs) with UUI and 11 age-matched controls.
  • Brain imaging techniques: white-matter hyperintensities (WMH), diffusion tensor imaging (DTI), and voxel-based morphometry (VBM).

Main Results:

  • UUI patients exhibited greater WMH burden globally and in specific white-matter tracts (superior longitudinal fasciculus, cingulum).
  • WMH burden was higher in BFB responders than non-responders, increasing in non-responders post-treatment.
  • DTI confirmed impaired cingulum integrity; VBM revealed parahippocampal atrophy in UUI patients.

Conclusions:

  • White-matter damage in critical bladder control pathways is common in women with UUI.
  • BFB training can improve bladder control, but therapeutic success may depend on the extent of neurological damage.
  • For some UUI patients, alternative therapeutic targets beyond central brain pathways may be necessary.