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Related Experiment Videos

Functional heterogeneity among human inducer T cell clones.

D T Umetsu1, H H Jabara, R H DeKruyff

  • 1Division of Allergy and Pulmonary Disease, Children's Hospital, Stanford, CA.

Journal of Immunology (Baltimore, Md. : 1950)
|June 15, 1988
PubMed
Summary
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Human CD4+ T cell clones show a complex lymphokine secretion pattern, unlike the simple Th1/Th2 dichotomy seen in mice. Some human T cells secrete multiple cytokines, challenging the established model.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Mouse CD4+ T cell clones exhibit a dichotomy in lymphokine secretion: Th1 cells produce IL-2 and IFN-gamma, while Th2 cells produce IL-4.
  • This Th1/Th2 paradigm is a fundamental concept in understanding T cell responses.

Purpose of the Study:

  • To investigate if a similar dichotomy exists in human CD4+ helper/inducer T cell clones.
  • To analyze lymphokine secretion patterns and functional activities of human T cell clones.

Main Methods:

  • Analysis of human CD4+ helper/inducer T cell clones.
  • Assessing lymphokine secretion profiles (IL-2, IFN-gamma, IL-4).
  • Evaluating functional activities, including Ig synthesis induction and B cell interactions.

Main Results:

Related Experiment Videos

  • Identified human T cell clones secreting IL-4 only, analogous to murine Th2 cells.
  • Observed human T cell clones secreting IL-2, IFN-gamma, and IL-4, unlike the strict murine dichotomy.
  • Southern blot confirmed multi-lymphokine secretion from single T cell clones.
  • IL-4 secretion did not consistently correlate with enhanced Ig synthesis; some clones showed potent B cell inhibitory activity.

Conclusions:

  • The strict Th1/Th2 dichotomy observed in mice may not fully apply to human T cells.
  • Human CD4+ T cell clones can exhibit more complex lymphokine secretion profiles.
  • The functional consequences of these complex profiles, particularly regarding B cell interactions, require further investigation.