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Camellimidazole A-C, Three Methylene-Bridged Dimeric Imidazole Alkaloids from Keemun Black Tea
Wei Wang1, Xing Tang1, Fang Hua1
1Natural Products Laboratory, International Joint Laboratory of Tea Chemistry and Health Effects, State Key Laboratory of Tea Plant Biology and Utilization , Anhui Agricultural University , Hefei 230036 , China.
Abstract:
Three new dimeric imidazole alkaloids with a methylene bridge, camellimidazole A-C (1-3), were isolated from Keemum black tea. Their structures were completely elucidated by a combination of diverse spectroscopic and single-crystal X-ray diffraction analyses. The plausible formation pathway of camellimidazole A-C was proposed. Compounds 1 and 2 exhibited remarkable protection against H2O2-induced neuronal damage at the concentration of 1.0 μM.
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