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Donated chemical probes for open science.

Susanne Müller1, Suzanne Ackloo2, Cheryl H Arrowsmith3

  • 1Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt am Main, Germany.

Elife
|April 21, 2018
PubMed
Summary

Pharmaceutical companies created a collaboration to share high-quality chemical probes and data. This initiative provides researchers with essential tools and guidance for selecting chemical probes, advancing scientific discovery.

Keywords:
Chemical probesOpen ScienceTarget validationbiochemistrychemical biology

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Area of Science:

  • Biochemistry and Chemical Biology
  • Drug Discovery and Development

Background:

  • Small molecule modulators, or chemical probes, are vital research reagents for studying protein function.
  • The pharmaceutical industry possesses numerous high-quality chemical probes, but associated data and control compounds are often inaccessible to academia.
  • Limited access to probe data and guidance hinders researchers in selecting appropriate chemical tools.

Purpose of the Study:

  • To describe a pre-competitive collaboration among pharmaceutical companies to make innovative chemical probes and associated data publicly available.
  • To provide researchers with access to high-quality chemical probes, control compounds, and usage recommendations.
  • To encourage broader participation in the Open Science Probes project.

Main Methods:

  • Formation of a pre-competitive collaboration involving multiple pharmaceutical companies (AbbVie, Bayer, Boehringer Ingelheim, Janssen, MSD, Pfizer, Takeda).
  • Compilation and dissemination of a large collection of high-quality chemical probes.
  • Inclusion of all probe-associated data, inactive control compounds, and usage recommendations.

Main Results:

  • A significant number of innovative, well-characterized chemical probes have been made available through the Open Science Probes initiative.
  • Comprehensive data, including control compounds and usage guidance, accompanies each chemical probe.
  • A dedicated online platform (
  • uri
  • xlink:href=
  • https://openscienceprobes.sgc-frankfurt.de
  • >https://openscienceprobes.sgc-frankfurt.de) hosts these resources.

Conclusions:

  • The Open Science Probes collaboration enhances accessibility of critical chemical biology tools for academic research.
  • This initiative aims to empower researchers by providing reliable data and well-characterized probes, facilitating informed tool selection.
  • The project encourages further contributions to expand the collective knowledge base of chemical probes and their applications.