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Perspectives on Neuroscience

Perspectives on Neuroscience

Published on: July 31, 2007

Molecular and Functional Neuroscience in Immunity.

Valentin A Pavlov¹, Sangeeta S Chavan¹, Kevin J Tracey¹

¹Center for Biomedical Science and Center for Bioelectronic Medicine, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York 11030, USA; email: vpavlov@northwell.edu , schavan@northwell.edu , kjtracey@northwell.edu.

Annual Review of Immunology

|April 21, 2018

Summary

The nervous system, through sensory and autonomic neurons, regulates immunity and inflammation via reflex pathways. This neuro-immune axis offers therapeutic potential in inflammatory and autoimmune diseases.

Keywords:

brain cytokines immunity inflammation nervous system vagus nerve

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Published on: July 31, 2007

Isolation of Functional Cardiac Immune Cells

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Published on: December 5, 2011

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

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Published on: February 16, 2016

Area of Science:

Neuroscience
Immunology
Physiology

Background:

The nervous system plays a crucial role in regulating immune responses and inflammation.
Sensory neurons detect immune molecules, initiating neural signals that modulate inflammation.
Autonomic efferent signaling is a key mechanism for neuro-immune communication.

Purpose of the Study:

To review the anatomical and molecular basis of the neural interface with immunity.
To focus on peripheral neural control of immune functions.
To outline clinical advances in bioelectronic medicine related to neuro-immune interactions.

Main Methods:

Review of anatomical and molecular data on neural control of immunity.
Analysis of reflex regulation principles in neuro-immune pathways.
Examination of therapeutic applications in inflammatory and autoimmune models and clinical settings.

Main Results:

Neural control of immunity is organized based on reflex principles.
Vagus nerve and other neural pathways are therapeutically relevant for inflammatory conditions.
The brain integrates neuro-immune signals, influencing both immune and brain function.

Conclusions:

Understanding the neuro-immune interface is critical for managing inflammatory and autoimmune diseases.
Bioelectronic medicine offers novel therapeutic strategies by targeting neural pathways.
The brain's role in immune regulation highlights the concept of the immunological homunculus.