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Updated: Feb 11, 2026

A Microfluidic Approach for the Study of Ice and Clathrate Hydrate Crystallization
Published on: August 18, 2022
Structures of a Clathrate Hydrate Former, Inhibitor, and Synergist in Water
Andrea Perrin1, Melissa J Goodwin1, Samantha Callear2
1Department of Chemistry , Durham University , Lower Mountjoy, Stockton Road , Durham DH1 3LE , United Kingdom.
Abstract:
SANS studies are reported for aqueous THF at the 1:17 clathrate hydrate-forming composition and on aqueous solutions of the synergist 2-butoxyethanol. Addition of the clathrate hydrate inhibitor polyvinylcaprolactam and a dimeric model compound, 1,3-bis(caprolactamyl)butane, show that the inhibitors do not significantly affect the solution structures of these two important species in clathrate hydrate formation and inhibition. The SANS studies show that 1,3-bis(caprolactamyl)butane is a good model for polyvinylcaprolactam, and both the polymer and model compound exhibit hydrogen bonding interactions with water but do not interact significantly with 2-butoxyethanol in aqueous solution.
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