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PBX1 promotes the cell proliferation via JAK2/STAT3 signaling in clear cell renal carcinoma

Xin Wei1, Lili Yu2, Yi Li2

  • 1Department of Urology, China-Japan Union Hospital of Jilin University, Changchun, 130033, Jilin, China.

Biochemical and Biophysical Research Communications
|April 22, 2018
PubMed

Insights

PBX1 overexpression drives renal clear cell carcinoma (ccRCC) by activating the JAK2/STAT3 pathway. Inhibiting PBX1 shows promise for future ccRCC treatments.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • PBX1 is overexpressed in various cancers, including renal clear cell carcinoma (ccRCC), with its oncogenic role and pathway involvement poorly understood.
  • Understanding PBX1's function in ccRCC is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate the role of PBX1 in ccRCC pathogenesis.
  • To explore the underlying signaling pathways, specifically the JAK2/STAT3 pathway, influenced by PBX1 in ccRCC.

Main Methods:

  • Analyzed PBX1 expression in 30 human ccRCC tissue pairs versus adjacent normal tissues.
  • Correlated PBX1 expression with patient survival rates.
  • Investigated the effect of PBX1 knockdown on JAK2/STAT3 signaling, STAT3 target genes (Cyclin D1), and ccRCC cell behavior in vitro and in vivo.

Main Results:

  • PBX1 expression was significantly upregulated in ccRCC tissues, correlating with poorer overall survival.
  • PBX1 expression positively correlated with JAK2 expression.
  • PBX1 knockdown suppressed STAT3 phosphorylation, reduced Cyclin D1 transcription, and inhibited ccRCC cell viability, proliferation, and cell cycle progression in vitro and in vivo.

Conclusions:

  • PBX1 acts as an oncogene in ccRCC by activating the JAK2/STAT3 pathway.
  • PBX1 is a potential therapeutic target for human ccRCC.
Keywords:
Cell proliferationClear cell renal carcinomaJAK2/STAT3 signalingPBX1

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