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Updated: Feb 11, 2026

Electrospinning Fibrous Polymer Scaffolds for Tissue Engineering and Cell Culture

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Published on: October 21, 2009

Electrospinning Functionalized Polymers for Use as Tissue Engineering Scaffolds.

Lesley W Chow^1,2

¹Department of Materials Science and Engineering, Lehigh University, Bethlehem, PA, USA. lesley.chow@lehigh.edu.

Methods in Molecular Biology (Clifton, N.J.)

|April 22, 2018

Summary

This summary is machine-generated.

Researchers modified poly(ε-caprolactone) (PCL) with peptides for tissue engineering scaffolds. This technique allows for controlled peptide presentation and gradient formation in a single step, enhancing scaffold functionality.

Keywords:

Biodegradable scaffold Electrospinning Functionalized polymers Gradient biomaterials Regenerative medicine Tissue engineering

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Elastomeric PGS Scaffolds in Arterial Tissue Engineering

Elastomeric PGS Scaffolds in Arterial Tissue Engineering

Published on: April 8, 2011

Area of Science:

Biomaterials Science
Tissue Engineering
Polymer Chemistry

Background:

Electrospinning polymers creates 3D fibrous scaffolds for tissue engineering.
Functionalizing polymers before electrospinning allows controlled presentation of bioactive cues.
Poly(ε-caprolactone) (PCL) is a common biomaterial for scaffold fabrication.

Purpose of the Study:

To describe methods for modifying PCL with peptides for electrospinning.
To functionalize scaffold surfaces with peptides in a single step.
To create peptide gradients within scaffolds using modified electrospinning.

Main Methods:

Chemical modification of PCL with peptides.
Electrospinning of peptide-PCL conjugates.
Adaptation of electrospinning setups for gradient formation.

Main Results:

Successful synthesis of peptide-PCL conjugates.
Generation of functionalized scaffolds with peptides on the surface.
Creation of single- and dual-peptide gradients within electrospun constructs.

Conclusions:

Peptide modification of PCL enables single-step scaffold functionalization.
Electrospinning peptide-PCL conjugates is a viable method for tissue engineering.
Gradient formation offers advanced control over scaffold bioactivity.