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Thermodynamic compatibility between cyclodextrin supramolecular complexes and surfactant.

Larissa H R Meira1, Guilherme A B Soares2, Homero I M Bonomini2

  • 1Laboratório de Sistemas Poliméricos e Supramoleculares (LSPS), Instituto de Física e Química, Universidade Federal de Itajubá (UNIFEI), Itajubá, 37500-903 MG, Brazil.

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Summary
This summary is machine-generated.

Cyclodextrin (CD) drug delivery systems face challenges with excipient compatibility. Losartan (LOS) remains in the CD cavity with sodium dodecyl sulfate (SDS), unlike atenolol (ATE), showing formulation stability differences.

Keywords:
Binding affinityCompetitionHost-guest interactionSupramolecular systemTheoretical calculationsThermodynamic parameters

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Area of Science:

  • Supramolecular Chemistry
  • Pharmaceutical Sciences
  • Drug Delivery

Background:

  • Cyclodextrins (CDs) are widely used in drug delivery systems.
  • Formulating inclusion complexes with excipients like sodium dodecyl sulfate (SDS) presents compatibility challenges.

Purpose of the Study:

  • To investigate the competitive interactions between SDS and two antihypertensive drugs, atenolol (ATE) and losartan (LOS), within cyclodextrin (CD) host-guest systems.
  • To determine the impact of SDS on the stability of ATE-CD and LOS-CD inclusion complexes.

Main Methods:

  • Nuclear Magnetic Resonance (NMR) spectroscopy
  • Isothermal Titration Calorimetry (ITC)
  • Molecular Dynamics (MD) simulations

Main Results:

  • Losartan (LOS) remained within the cyclodextrin (CD) cavity upon addition of sodium dodecyl sulfate (SDS).
  • Atenolol (ATE) was displaced from the cyclodextrin (CD) cavity by sodium dodecyl sulfate (SDS) in the ternary system.
  • Differential stability of inclusion complexes was observed based on the drug-excipient interactions.

Conclusions:

  • The study highlights the differential compatibility of antihypertensive drugs with common pharmaceutical excipients in cyclodextrin-based formulations.
  • Understanding these competitive interactions is crucial for designing stable and effective drug delivery systems.
  • Losartan exhibits superior stability in the presence of SDS within cyclodextrin complexes compared to atenolol.