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Published on: November 15, 2012
Naturally occurring aromatic steroids and their biological activities
Valery M Dembitsky1,2, Nick Savidov3, Vladimir V Poroikov4
1Centre for Applied Research and Innovation, Lethbridge College, 3000 College Drive South, Lethbridge, AB, T1K 1L6, Canada. valeryde@imb.dvo.ru.
Abstract:
The present review describes the distribution and biological activities of natural mono-, di-, and triaromatic steroids. It is shown that the producers of aromatic steroids are microorganisms, fungi, and marine invertebrates, and also they were found in plants, animals, marine sediments, and karst deposits. Eighty biologically active aromatic steroids likely have an anti-tumor, anti-inflammatory, and neuroprotection activity with a confidence of 78 to 92%. The structures and predicted biological activities of aromatic steroids are available. This review emphasizes the role of aromatic steroids as an important source and potential leads for drug discovery and they are of great interest to chemists, physicians, biologists, pharmacologists, and the pharmaceutical industry.
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