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Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye
Published on: March 30, 2020
Transmucosal delivery of melatonin-encapsulated niosomes in a mucoadhesive gel
Aroonsri Priprem1,2, Chatchanok Nukulkit2, Nutjaree P Johns2,3
1Division of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.
Aim:
A transmucosal niosome gel was developed to improve the pharmacokinetics of exogenous melatonin.
Materials & Methods:
The melatonin niosomes (MN) gel was characterized and melatonin levels were determined in healthy volunteers.
Results:
Micron-sized MN in a gel, mean ex vivo residence time of more than 3 h with maximum adhesiveness at 25 and 37°C showed similar in vitro release but different in vitro permeation to melatonin gel. Oral transmucosal MN gels, at 2.5, 5 and 10 mg, topically applied in 14 healthy volunteers in a randomized double-blinded crossover design with 7-day washout, gave dose-proportional pharmacokinetics, with improved absorption and prolonged systemic circulation.
Conclusion:
The transmucosal MN gel provides a topical option for melatonin administration with substantial prolonged systemic delivery.
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