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Updated: Aug 20, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

Herpesvirus-like DNA Sequences in Japanese Patients with AIDS-related Kaposi's Sarcoma

Natsuo Tachikawa1, Mieko Goto1, Hiroyuki Gatanaga1

  • 1Department of Infectious Diseases, Institute of Medical Science, University of Tokyo.

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|April 24, 2018
PubMed

Insights

Researchers investigated Kaposi

Area of Science:

  • Oncology
  • Virology
  • Pathogenesis

Background:

  • The etiology of Kaposi's sarcoma (KS) is not fully understood.
  • A novel human gamma herpesvirus, now known as Kaposi's sarcoma-associated herpesvirus (KSHV), has been implicated in KS pathogenesis.

Purpose of the Study:

  • To investigate the presence of Kaposi's sarcoma-associated herpesvirus (KSHV) sequences in Japanese patients with Kaposi's sarcoma.
  • To determine the association of KSHV with KS lesions.

Main Methods:

  • Examination of DNA from three Japanese patients for KSHV sequences.
  • Analysis of KSHV sequence distribution in relation to KS tissue invasion.

Main Results:

  • KSHV sequences were detected in two out of three Japanese KS patients.
  • KSHV sequences were predominantly found in tissues with Kaposi's sarcoma invasion.
  • One patient's sample was inconclusive due to DNA degradation.

Conclusions:

  • These findings support the presence of KSHV in Kaposi's sarcoma lesions.
  • The results further implicate KSHV in the pathogenesis of Kaposi's sarcoma.
Keywords:
AIDSKaposi's sarcomaherpesvirus-like DNA sequences

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