A Microbiota-Dependent, STAT3-Driven Mouse Model of Cutaneous T-Cell Lymphoma

In recent years, much has been learned about the molecular genetics of cutaneous T-cell lymphomas. Fanok et al. (2018) translate knowledge from systematic genomic and transcriptomic analyses to develop a mouse model that tests the hypothesis that activated STAT3 in CD4⁺ T cells may be a driver of cutaneous T-cell lymphomas. The transgenic mouse that they developed exhibits clinical features of mycosis fungoides, as well as Sezary syndrome, two well-known entities in the cutaneous T-cell lymphoma spectrum. Furthermore, these authors show that TCR engagement and microbiota are required for development of the complete clinical phenotype. This mouse model, which develops progressive disease, provides a new tool to understand cutaneous T-cell lymphoma biology and to potentially test new therapies.