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Updated: Feb 11, 2026
10:51
The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
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Half-Sandwich Arene Ruthenium(II) and Osmium(II) Thiosemicarbazone Complexes: Solution Behavior and Antiproliferative
Anna Gatti1,2, Abraha Habtemariam2, Isolda Romero-Canelón2,3
1Dipartimento di Scienze Chimiche, della Vita e della Sostenibilità Ambientale and CIRCMSB (Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici), University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.
Organometallics
|April 24, 2018
Summary
New organo-osmium(II) and organo-ruthenium(II) complexes show significant antiproliferative activity against various cancer cells. Ruthenium complex 3 demonstrates efficacy without cross-resistance to cisplatin in ovarian cancer.
Area of Science:
- Inorganic Chemistry
- Medicinal Chemistry
- Materials Science
Background:
- Organometallic complexes offer unique structural and electronic properties for therapeutic applications.
- Thiosemicarbazone ligands are known for their diverse biological activities, including anticancer properties.
- Developing novel metal-based anticancer agents with improved efficacy and reduced resistance is a critical area of research.
Purpose of the Study:
- To synthesize and characterize novel organo-osmium(II) and organo-ruthenium(II) half-sandwich complexes.
- To evaluate the antiproliferative activity of these complexes against a panel of human cancer cell lines.
- To investigate the structure-activity relationships and potential for overcoming drug resistance.
Main Methods:
- Synthesis of four organometallic complexes: [(η6-p-cym)Os(L)Cl]Cl (1 and 2) and [(η6-p-cym)Ru(L)Cl]Cl (3 and 4), where L represents two distinct thiosemicarbazone ligands (L1 and L2).
- Characterization using X-ray crystallography to determine the 'three-legged piano-stool' structure.
- In vitro antiproliferative assays against A2780 ovarian, A2780Cis cisplatin-resistant ovarian, A549 lung, HCT116 colon, and PC3 prostate cancer cells.
Main Results:
- All synthesized complexes exhibit a pseudo-octahedral half-sandwich structure with N,S-chelating thiosemicarbazone ligands.
- Complexes displayed significant antiproliferative activity across multiple cancer cell lines.
- Ruthenium complex 3 showed no cross-resistance with cisplatin in A2780 ovarian cancer cells, and complexes demonstrated up to 20-fold improved potency compared to free ligands.
Conclusions:
- The novel organo-osmium(II) and organo-ruthenium(II) complexes are promising anticancer agents.
- Ruthenium complex 3 represents a potential therapeutic candidate for cisplatin-resistant ovarian cancers.
- The study highlights the potential of metal-thiosemicarbazone complexes in cancer therapy, offering enhanced activity and overcoming resistance mechanisms.
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