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Good Outcomes with the Intraventricular Vancomycin Therapy in a Patient with Ruptured Brain Abscesses

Ninh Doan1, Ha Nguyen1, Li Luyuan2

  • 1Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA.

Asian Journal of Neurosurgery
|April 24, 2018
PubMed

Insights

Intraventricular vancomycin offers a promising treatment for brain abscesses that rupture into the ventricles (IVROBA). This approach showed significant improvement in a patient refractory to standard antibiotic therapy.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Neurosurgery

Background:

  • Brain abscesses carry high morbidity and mortality.
  • Intraventricular rupture of brain abscess (IVROBA) has a particularly grim prognosis, with mortality rates up to 85%.
  • Effective treatment options for IVROBA refractory to intravenous antibiotics and surgical drainage are limited.

Observation:

  • A patient with IVROBA deteriorated despite systemic antibiotic treatment.
  • Intraventricular vancomycin therapy was initiated in this refractory case.

Findings:

  • The patient demonstrated remarkable clinical improvement following intraventricular vancomycin administration.
  • No discernible side effects were observed during the intraventricular vancomycin treatment.

Implications:

  • Intraventricular vancomycin may represent a safe and effective therapeutic option for IVROBA.
  • This approach could be particularly valuable for patients with IVROBA who do not respond to conventional systemic treatments.
Keywords:
Brain abscessintracerebral rupture of brain abscessintraventricular vancomycinventricultiis

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