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Upfront Radiotherapy with Concurrent and Adjuvant Vismodegib Is Effective and Well-Tolerated in a Patient with
Abigail I Franco1, Gary Eastwick2, Ramsay Farah2
1St. Joseph's Hospital Health Center, 301 Prospect Avenue, Syracuse, NY 13203, USA.
Case Reports in Dermatological Medicine
|April 24, 2018
Summary
This case report details a patient with extensive basal cell carcinoma treated with radiation and vismodegib. The combination therapy achieved a complete response, offering a new treatment option for advanced cases.
Area of Science:
- Oncology
- Dermatology
- Radiation Oncology
Background:
- Basal cell carcinoma (BCC) can present as multifocal and extensive disease.
- Surgical resection is the standard treatment but may not be feasible for large, deeply infiltrating tumors.
- Combined modality treatments are explored for advanced BCC, particularly in palliative or recurrent settings.
Observation:
- A male patient presented with multifocal and extensive basal cell carcinoma.
- The patient was not a surgical candidate due to tumor size and depth.
- A treatment plan involving fractionated radiation therapy concurrent with vismodegib was selected.
Findings:
- This represents the first reported case of concurrent vismodegib and radiation therapy for upfront definitive management of advanced BCC.
- The patient achieved a complete response in all treated lesions.
- The combined modality treatment was well-tolerated.
Implications:
- Concurrent vismodegib and radiation therapy is a viable and effective upfront treatment strategy for unresectable, extensive basal cell carcinoma.
- This approach may offer a new paradigm for definitive management of advanced BCC.
- Further research is warranted to evaluate this combination in larger patient cohorts.
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