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Adult-onset Minimal Change Disease with IgA Nephropathy and Hepatitis C

Waliul Chowdhury1, Tahira Sabeen Saleem2, Muhammad Uzair Lodhi1

  • 1Medical Student, Department of Medicine, Raleigh General Hospital, Beckley, Wv.

Cureus
|April 24, 2018
PubMed

Insights

Minimal change disease (MCD) is a common cause of nephrotic syndrome in children. This rare adult-onset case highlights the importance of suspecting MCD in adults presenting with nephrotic symptoms.

Area of Science:

  • Nephrology
  • Immunology

Background:

  • Minimal change disease (MCD) is a primary cause of nephrotic syndrome in children.
  • It is less common in adults, making diagnosis challenging.
  • Adult-onset MCD, especially with co-existing IgA nephropathy, is exceptionally rare.

Observation:

  • A 44-year-old male with a history of Hepatitis C Virus (HCV) presented with acute lower extremity edema.
  • Daily proteinuria measured at 6.6 grams was noted.
  • Electron microscopy revealed podocyte effacement, a key indicator for MCD.

Findings:

  • The patient's presentation mimicked typical nephrotic syndrome.
  • Despite the patient's age and HCV history, the diagnostic findings pointed towards Minimal Change Disease.
  • Co-existence of IgA nephropathy was suspected, though not explicitly confirmed in the abstract.

Implications:

  • Physicians should consider Minimal Change Disease in adults presenting with nephrotic syndrome, irrespective of age.
  • Early suspicion and diagnostic workup are crucial for timely management.
  • Understanding rare presentations of MCD aids in improving diagnostic accuracy in adult nephrology.
Keywords:
hepatitis ciga nephropathyminimal change disease

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