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Updated: Feb 11, 2026

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Pd-Catalyzed asymmetric decarboxylative cycloaddition of vinylethylene carbonates with 3-cyanochromones
Ijaz Khan1, Can Zhao, Yong Jian Zhang
1School of Chemistry and Chemical Engineering, and Shanghai Key Laboratory of Electrical Insulation and Thermal Aging, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China. yjian@sjtu.edu.cn.
Abstract:
An efficient method for the construction of furanobenzodihydropyran skeletons has been developed through Pd-catalyzed asymmetric decarboxylative cycloaddition of vinylethylene carbonates with 3-cyanochromones. By using a palladium complex generated in situ from [Pd2(dba)3]·CHCl3 and phosphoramidite L3 as a catalyst under mild reaction conditions, the process afforded furanobenzodihydropyrans bearing vicinal quaternary stereocenters in high yields with good to high enantio- and diastereoselectivities.
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