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Right atrial dilatation increases inositol-(1,4,5)trisphosphate accumulation. Implications for the control of atrial
R von Harsdorf1, R Lang, M Fullerton
1German Institute for High Blood Pressure Research, Heidelberg, FRG.
FEBS Letters
|June 6, 1988
Abstract:
Stretching the right atrium of isolated perfused [3H]inositol-labelled rat hearts was shown to stimulate the phosphatidyl-inositol turnover pathway as demonstrated by the accumulation of [3H]inositol-(1,4,5)trisphosphate and its degradation products. Stimulation was detectable after 1 min with larger increases observed after 10 or 20 min. These findings demonstrate that the myocardium can respond to dilatation by an activation of the phosphatidylinositol turnover pathway. Such a mechanism has implications for the release of atrial natriuretic peptide following right atrial distention.