Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kidney Structure01:45

Kidney Structure

75.5K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
75.5K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

689
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
689
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

1.1K
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
1.1K
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

1.1K
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
1.1K
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

498
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
498
External Anatomy of the Kidney01:21

External Anatomy of the Kidney

3.9K
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sequential emergence of hematuria and proteinuria in autosomal dominant Alport syndrome: a pathophysiological perspective.

European journal of pediatrics·2026
Same author

Rethinking monosymptomatic nocturnal enuresis as a developmental variation.

European journal of pediatrics·2026
Same author

The overlooked role of infectious foci in IgA vasculitis: a call for renewed clinical awareness.

Pediatric research·2026
Same author

Correction: Web-based machine learning application for ambulation prognosis in the rehabilitation phase of spinal cord injury: a retrospective multicenter cohort study.

Spinal cord·2026
Same author

A maternal exon H splice-site variant leading to pseudohypoparathyroidism type 1B with broad methylation defects in GNAS-differentially methylated regions.

Clinical epigenetics·2026
Same author

Differences in International Recommendations for Piperacillin Dosing: A Japanese Perspective.

JMA journal·2026

Related Experiment Video

Updated: Feb 11, 2026

Robot-Assisted Kidney Transplantation
07:30

Robot-Assisted Kidney Transplantation

Published on: July 19, 2021

4.4K

Down syndrome and mild kidney dysfunction.

Satoshi Yamakawa1, Takuhito Nagai1, Osamu Uemura1

  • 1Department of Pediatric Nephrology, Aichi Children's Health and Medical Center, Obu, Aichi, Japan.

Pediatrics International : Official Journal of the Japan Pediatric Society
|April 24, 2018
PubMed
Summary

Children with Down syndrome (DS) show reduced kidney function, approximately 80% of healthy peers. This suggests DS patients may have smaller kidneys or fewer glomeruli, impacting renal health.

Keywords:
Down syndromechildrenglomerular filtration ratekidney function

More Related Videos

The Mouse Isolated Perfused Kidney Technique
08:19

The Mouse Isolated Perfused Kidney Technique

Published on: November 17, 2016

23.4K
Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
08:12

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

Published on: July 15, 2015

19.9K

Related Experiment Videos

Last Updated: Feb 11, 2026

Robot-Assisted Kidney Transplantation
07:30

Robot-Assisted Kidney Transplantation

Published on: July 19, 2021

4.4K
The Mouse Isolated Perfused Kidney Technique
08:19

The Mouse Isolated Perfused Kidney Technique

Published on: November 17, 2016

23.4K
Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
08:12

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

Published on: July 15, 2015

19.9K

Area of Science:

  • Pediatric Nephrology
  • Genetics
  • Down Syndrome Research

Background:

  • Limited detailed evaluations of kidney function in pediatric Down syndrome (DS) patients exist.
  • Understanding renal health in DS is crucial for comprehensive patient care.
  • This study focuses on DS children without confounding kidney-affecting complications.

Purpose of the Study:

  • To investigate and quantify kidney function in pediatric patients with Down syndrome.
  • To compare the estimated glomerular filtration rate (eGFR) in DS children to healthy controls.
  • To explore potential underlying reasons for observed differences in renal function.

Main Methods:

  • Measurement of creatinine (Cr) and cystatin C (cysC) levels.
  • Calculation of estimated glomerular filtration rate (eGFR) using established formulas.
  • Cohort study involving Japanese pediatric patients with Down syndrome.

Main Results:

  • Pediatric DS patients exhibited eGFR approximately 80% of that in healthy Japanese children.
  • This indicates a significant difference in kidney function compared to the general pediatric population.
  • No complications affecting kidney function were present in the studied DS cohort.

Conclusions:

  • Children with Down syndrome demonstrate reduced kidney function compared to healthy children.
  • The findings suggest a potential difference in kidney size or glomerular number in DS patients.
  • Further research into the renal morphology and long-term kidney health of DS individuals is warranted.