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Toxicological hair analysis: Pre-analytical, analytical and interpretive aspects.
Himanshu Khajuria1, Biswa Prakash Nayak1, Ashish Badiye2
11 Amity Institute of Forensic Sciences, Amity University, India.
Medicine, Science, and the Law
|April 24, 2018
Summary
Hair analysis offers a longer detection window for drugs of abuse compared to traditional methods. Chromatography enhances drug detection in hair, but challenges remain in interpreting results accurately.
Area of Science:
- Forensic Toxicology
- Analytical Chemistry
Background:
- Hair analysis is a key forensic toxicology technique for drug detection.
- It offers a longer detection window than urine or blood analysis.
- Hair analysis is non-invasive and requires minimal specialized training for sample collection.
Purpose of the Study:
- To investigate the efficacy of chromatography for detecting drugs of abuse in hair.
- To summarize current practices and challenges in hair drug analysis.
- To discuss factors influencing drug incorporation and detection in hair.
Main Methods:
- A comprehensive literature review of hair analyses from the past two decades.
- Analysis of PubMed and similar databases.
- Discussion of hair physiochemistry, drug incorporation mechanisms, and stability.
Main Results:
- Hair analysis provides a longer detection timeframe and is less invasive than traditional methods.
- Advances in analytical technology have improved sensitivity, reproducibility, and accuracy.
- Chromatography is an effective method for drug detection in hair samples.
Conclusions:
- While hair analysis offers advantages, result interpretation is challenging due to potential external contamination leading to false-positives.
- Further development of sensitive and selective analytical methods is needed.
- Minimizing factors like melanin and age effects will enhance hair analysis applications.
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