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A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

The function and failure of sensory predictions.

Sonia Bansal¹, Judith M Ford², Miriam Spering³

¹Maryland Psychiatric Research Center, University of Maryland, Catonsville, Maryland.

Annals of the New York Academy of Sciences

|April 24, 2018

Summary

This review explores how the brain predicts future events using corollary discharge. Impaired prediction mechanisms are linked to neuropsychiatric conditions like hallucinations and delusions.

Keywords:

corollary discharge efference copy hallucination predictive coding schizophrenia

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Area of Science:

Neuroscience
Cognitive Science
Psychiatry

Background:

Humans and primates possess neural mechanisms for automatic prediction of future events.
Prediction-driven control is essential for normal perception and motor actions.
Corollary discharge is a key neural mechanism underlying these predictions.

Purpose of the Study:

To review corollary discharge mechanisms in prediction across sensory modalities.
To discuss the impact of predictive coding on cognition and behavior.
To link prediction failures to neuropsychiatric symptoms.

Main Methods:

Review of existing literature on corollary discharge and predictive coding.
Analysis of psychophysical and psychophysiological studies.
Examination of neural correlates of prediction function and failure.

Main Results:

Converging evidence implicates impaired corollary discharge in neuropsychiatric symptoms.
A prediction-failure hypothesis explains perceptual and cognitive disturbances.
Similarities in prediction mechanisms exist across visual, auditory, and somatosensory systems.

Conclusions:

Understanding prediction mechanisms and failures offers insights into disease mechanisms.
Corollary discharge impairments contribute to symptoms like hallucinations and delusions.
This review bridges basic science findings with clinical relevance in neuropsychiatry.