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Updated: Feb 11, 2026
10:14
Biochemical Assays for Analyzing Activities of ATP-dependent Chromatin Remodeling Enzymes
Published on: October 25, 2014
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ATP-Dependent Chromatin Remodeling During Cortical Neurogenesis
Godwin Sokpor1, Ricardo Castro-Hernandez1, Joachim Rosenbusch1
1Institute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen, Goettingen, Germany.
Frontiers in Neuroscience
|April 25, 2018
Summary
Chromatin remodelers precisely control gene expression for neuron development. This review details how these complexes orchestrate cortical neurogenesis, ensuring proper brain formation and function.
Area of Science:
- Neuroscience
- Developmental Biology
- Molecular Biology
Background:
- Cortical development involves intricate neurogenesis, regulated by specific gene expression programs.
- Neural progenitor proliferation, differentiation, and neuronal migration/maturation are critical for brain development.
- ATP-dependent chromatin remodelers are key regulators of gene expression via chromatin structure modification.
Purpose of the Study:
- To review the functions of ATP-dependent chromatin remodelers in cortical development.
- To elucidate the mechanisms by which these remodelers modulate cortical neurogenesis.
Main Methods:
- Literature review of studies on chromatin remodelers and cortical neurogenesis.
- Analysis of proposed mechanisms of chromatin remodeler action.
Main Results:
- Chromatin remodelers are multimeric complexes that can adopt distinct conformations.
- These complexes play vital roles in regulating gene expression during neurogenesis.
- Specific mechanisms of individual and concerted action are proposed.
Conclusions:
- ATP-dependent chromatin remodelers are essential for orchestrating cortical neurogenesis.
- Understanding their function is crucial for comprehending normal brain development and potential disorders.
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