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A difference amplifier, a crucial component in numerous electronic devices, ideally amplifies only the difference-mode signal, which is the difference between two input signals. However, in practical circuits, the output voltage depends on both the differential gain and the common-mode gain.
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Updated: Feb 11, 2026

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[CCTA-derived FFR in clinical practise].

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Coronary computed tomography angiography (CCTA) accurately assesses some coronary artery blockages. Simulated fractional flow reserve computed tomography (FFRCT) analysis may reduce the need for invasive procedures for intermediate stenosis.

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Area of Science:

  • Cardiovascular imaging and diagnostics
  • Interventional cardiology

Background:

  • Coronary computed tomography angiography (CCTA) is a valuable non-invasive tool for evaluating coronary artery stenosis.
  • Intermediate-grade coronary stenosis often requires invasive coronary angiography for definitive assessment.

Observation:

  • Simulated fractional flow reserve computed tomography (FFRCT) analysis offers a non-invasive method to evaluate the functional significance of coronary stenosis.
  • This approach has the potential to reduce the number of invasive procedures performed for intermediate stenosis.

Findings:

  • CCTA accurately identifies high- and low-grade coronary stenosis.
  • FFRCT analysis provides a non-invasive evaluation of stenosis severity, potentially aiding in clinical decision-making.

Implications:

  • The implementation of simulated FFRCT analysis at Helsingborg Hospital marks a significant advancement in non-invasive cardiac diagnostics in Sweden.
  • This technology may optimize patient management pathways, reducing the need for invasive coronary angiography in select cases.