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Hematuria as an adverse outcome following provocative growth hormone stimulation testing in children

Rajeev Thirunagari1, Alexandra Marrone2, Hannah Elsinghorst2

  • 1Division of Pediatric Endocrinology, Children's Hospital of Michigan, Detroit, MI, USA.

Journal of Pediatric Endocrinology & Metabolism : JPEM
|April 25, 2018
PubMed

Insights

Hematuria, or blood in urine, occurred in three children after growth hormone (GH) stimulation testing. This side effect, while self-limiting, is not rare and should be discussed with families before testing.

Area of Science:

  • Pediatric Endocrinology
  • Clinical Diagnostics

Background:

  • Growth hormone (GH) stimulation testing is crucial for diagnosing short stature and growth failure in children.
  • Commonly used agents include clonidine, arginine, and glucagon.
  • While generally safe, rare instances of hematuria following GH testing have been reported.

Purpose of the Study:

  • To determine the incidence of microscopic and macroscopic hematuria after GH stimulation testing using various agents.
  • To characterize the occurrence and resolution of hematuria as a complication of GH testing.

Main Methods:

  • 34 children undergoing GH stimulation testing were enrolled.
  • Baseline urinalysis and vital signs were recorded before testing.
  • Participants performed home urine testing on days 1, 2, 3, and 7 post-testing.

Main Results:

  • Three subjects (8.8%) developed hematuria after receiving clonidine/arginine for GH testing.
  • Hematuria resolved spontaneously within 7 days.
  • Other adverse effects included nausea, vomiting, and hypotension.

Conclusions:

  • Hematuria is a complication of GH stimulation testing in children, observed in this study.
  • The side effects associated with GH testing agents are generally self-limiting but warrant discussion with patients and families.
  • This highlights the importance of informed consent regarding potential adverse events.
Abstract

Keywords:
arginineclonidinegrowth hormone deficiencyhematuriapediatricshort stature

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