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Photodynamic therapy of cancer
1Division of Cancer Treatment, National Cancer Institute, Bethesda, MD 20892.
Comprehensive Therapy
|May 1, 1988
Summary
Photodynamic therapy (PDT) using photoactivated hematoporphyrins shows antitumor activity. Research is ongoing to optimize PDT for various cancers, particularly superficial tumors and in combination with other treatments.
Area of Science:
- Oncology
- Photochemistry
- Medical Technology
Background:
- Photodynamic therapy (PDT) utilizes photoactivated hematoporphyrins for cancer treatment.
- Early clinical studies focused on advanced, recurrent malignancies unresponsive to conventional therapies.
Purpose of the Study:
- To define optimal sites and applications for PDT in human malignancy treatment.
- To investigate alternative photosensitizers and improve PDT dosimetry.
Main Methods:
- Clinical trials evaluating hematoporphyrin derivative PDT in various cancer sites.
- Laboratory research on photosensitizer properties and singlet oxygen measurement.
Main Results:
- Good responses with acceptable toxicity observed in patients with advanced disease.
- Promising applications identified for superficial tumors and in combination with debulking strategies.
Conclusions:
- PDT shows potential for treating specific cancer types, especially superficial lesions.
- Further research aims to enhance photosensitizer efficacy, light penetration, and dosimetry for improved cancer treatment outcomes.