Related Experiment Video

Updated: Feb 11, 2026

Canine Intestinal Organoids in a Dual-Chamber Permeable Support System
11:11

Canine Intestinal Organoids in a Dual-Chamber Permeable Support System

Published on: March 2, 2022

4.3K

Phase I/II evaluation of RV1001, a novel PI3Kδ inhibitor, in spontaneous canine lymphoma

Heather L Gardner1, Sarah B Rippy2, Misty D Bear3

  • 1Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America.

Plos One
|April 25, 2018
PubMed
Abstract

Insights

RV1001, a PI3Kδ inhibitor, demonstrated significant efficacy and an acceptable safety profile in canine Non-Hodgkin lymphoma (NHL) studies. This novel drug showed promising response rates in both naive and resistant B and T-cell NHL cases.

Area of Science:

  • Oncology
  • Pharmacology
  • Veterinary Medicine

Background:

  • Non-Hodgkin lymphoma (NHL) is a significant concern in canine oncology.
  • PI3Kδ (Phosphoinositide 3-kinase delta) is a key signaling pathway implicated in various lymphomas.
  • Novel therapeutic strategies targeting PI3Kδ are being explored for canine NHL.

Purpose of the Study:

  • To evaluate the safety and efficacy of RV1001, a novel PI3Kδ inhibitor, in dogs with Non-Hodgkin lymphoma (NHL).
  • To determine the recommended starting dose for further clinical trials in canine NHL.
  • To assess the pharmacokinetic profile and therapeutic response to RV1001.

Main Methods:

  • Inhibition of pAKT by RV1001 in primary canine NHL cells was assessed using Western blotting.
  • A Phase I clinical trial involved 21 dogs with naïve and drug-resistant T and B-cell NHL.
  • A subsequent Phase II exploratory trial included 35 dogs to further define efficacy and safety.

Main Results:

  • Phase I study showed an objective response rate of 62% (3 CR, 10 PR) in canine NHL.
  • Phase II study reported an objective response rate of 77% (1 CR, 26 PR).
  • Clinical toxicities were mainly hepatobiliary and gastrointestinal, with hepatotoxicity as the dose-limiting toxicity.

Conclusions:

  • RV1001 demonstrated good oral bioavailability, an acceptable safety profile, and biological activity in canine B and T-cell NHL.
  • The drug effectively inhibited pAKT, a key signaling molecule, in canine lymphoma.
  • Findings support the potential of RV1001 and inform future human clinical trial designs for PI3K inhibitors.

More Related Videos

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents14:04

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents

Published on: March 25, 2016

15.9K
Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia10:49

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

18.7K

Related Concept Videos

Spontaneity02:21

Spontaneity

A spontaneous process is one that occurs naturally under certain conditions. A nonspontaneous process, on the other hand, will not take place unless it is “driven” by the continual input of energy from an external source. Processes have a natural tendency to occur in one direction under a given set of conditions. Water will naturally flow downhill (spontaneous process), but uphill flow (nonspontaneous process) requires outside intervention such as the use of a pump. Iron exposed to...
30.1K
Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
11.1K
Phase Diagrams02:39

Phase Diagrams

A phase diagram combines plots of pressure versus temperature for the liquid-gas, solid-liquid, and solid-gas phase-transition equilibria of a substance. These diagrams indicate the physical states that exist under specific conditions of pressure and temperature and also provide the pressure dependence of the phase-transition temperatures (melting points, sublimation points, boiling points). Regions or areas labeled solid, liquid, and gas represent single phases, while lines or curves represent...
50.4K
Phase Transitions02:31

Phase Transitions

Whether solid, liquid, or gas, a substance's state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the solid pack closely together, generally in a pattern. The particles vibrate about their fixed positions but do not move or squeeze past their neighbors. In liquids, although the particles are closely spaced, they are randomly arranged. The position of the particles are not fixed—that is, they are free to move past their neighbors to...
23.3K
Spontaneous and Induced Mutations01:30

Spontaneous and Induced Mutations

Spontaneous mutations arise infrequently during DNA replication due to errors in the process. A key factor behind these errors is tautomeric shifts in nitrogenous bases, where bases transition from keto to enol forms or amino to imino forms. This shift can alter base-pairing rules, leading to mutations. Additionally, reactive oxygen species (ROS) arising from aerobic metabolism can damage DNA, resulting in depurination (loss of a purine base) or depyrimidination (loss of a pyrimidine base).
2.3K
Inductance: Single-Phase And Three-Phase Line01:28

Inductance: Single-Phase And Three-Phase Line

Understanding the inductance of transmission lines is crucial for efficient design and operation in electrical power systems. This discussion delves into the inductance characteristics of single-phase two-wire and three-phase three-wire transmission lines with equal phase spacing.
Single-Phase Two-Wire Line:
A single-phase line consists of two solid cylindrical conductors, denoted as x and y. Each conductor carries phasor currents ix and iy, respectively. Given that the sum of these currents is...
643