Related Experiment Video
Updated: Feb 11, 2026
08:40
A Blood-Free Diet to Rear Anopheline Mosquitoes
Published on: January 31, 2020
11.3K
The ketogenic diet in disease and development.
Denis Barry1, Sarah Ellul1, Lindsey Watters1
1Department of Anatomy Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Summary
The ketogenic diet, a high-fat, low-carb eating plan, is explored for its effects on brain energy metabolism. This review examines ketone body utilization and its impact on brain development, particularly during pregnancy.
Area of Science:
- Neuroscience
- Metabolic Disorders
- Nutritional Science
Background:
- The ketogenic diet, characterized by low carbohydrate and high fat intake, was initially developed for epilepsy management.
- Emerging research indicates its therapeutic potential for movement disorders, psychological conditions, and overall health.
- While ketone body metabolism's role in the central nervous system is increasingly understood, its impact during pregnancy remains unclear.
Purpose of the Study:
- To review the functional outcomes of ketone body metabolism and monocarboxylic transporter expression during development and adulthood.
- To discuss the therapeutic applications of ketone bodies.
- To specifically examine the effects of a maternal ketogenic diet on the developing brain.
Main Methods:
- Literature review focusing on studies investigating ketone body metabolism.
- Analysis of research on monocarboxylic transporter expression in the brain.
- Synthesis of findings related to developmental and adult neurological function.
Main Results:
- Ketone bodies serve as an alternative energy source for the brain, influencing neurological function.
- Monocarboxylic transporters are crucial for delivering ketone bodies across the blood-brain barrier.
- Maternal ketogenic diet can impact fetal brain development, though mechanisms require further investigation.
Conclusions:
- Ketone body metabolism plays a significant role in both developing and adult brains.
- Understanding ketone body utilization offers potential therapeutic strategies for neurological disorders.
- Further research is needed to elucidate the long-term effects of maternal ketogenic diets on offspring neurodevelopment.
More Related Videos
10:31An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
Published on: April 20, 2018
11.2K
07:05Behavioral Disturbances: An Innovative Approach to Monitor the Modulatory Effects of a Nutraceutical Diet
Published on: January 3, 2017
9.4K
Related Concept Videos
01:43Sustainable Development
15.2K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
15.2K
01:30Inflammatory Bowel Disease II: Crohn's Disease
1.2K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.2K
01:22Language Development
936
Children master language quickly and with relative ease, supported by both biological predisposition and reinforcement. B. F. Skinner (1957) proposed that language is learned through reinforcement, while Noam Chomsky (1965) argued that language acquisition mechanisms are biologically determined.
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
936
01:15Development of the Lymphatic System
2.2K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
2.2K
01:25Immunodeficiency Diseases
2.5K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
2.5K
01:22Development of Immunocompetence
987
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
987