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Immune system and obsessive-compulsive disorder.

Donatella Marazziti1, Federico Mucci1, Leonardo F Fontenelle2

  • 1Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry, University of Pisa, and Brain Research Foundation Lucca, Italy.

Psychoneuroendocrinology
|April 25, 2018
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Summary

Research suggests a link between the immune system and obsessive-compulsive disorder (OCD). Studies indicate immune alterations in OCD patients, hinting at potential immunotherapeutic treatments for this condition.

Keywords:
Adult OCDCANSChildood OCDCytokinesImmune systemObsessive-compulsive disorderPANDASPANSStreptococcus infections

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Area of Science:

  • Neuroscience
  • Immunology
  • Psychiatry

Background:

  • Growing interest in immune system alterations in obsessive-compulsive disorder (OCD).
  • Existing literature suggests a potential connection between immune function and OCD pathophysiology.

Purpose of the Study:

  • To review and synthesize current literature on the relationship between OCD and the immune system.
  • To explore the role of immune processes in the development and manifestation of OCD.

Main Methods:

  • Comprehensive literature search conducted on PubMed and Google Scholar.
  • Utilized specific keywords to identify relevant studies on OCD and immunology.

Main Results:

  • Childhood OCD is linked to streptococcal infections, evolving into pediatric acute-onset neuropsychiatric syndrome (PANS/CANS).
  • Adult OCD patients show distinct immunological parameters compared to controls, though studies are limited and often small-scale.

Conclusions:

  • The precise relationship between OCD and immune processes remains to be fully elucidated.
  • Current evidence supports the involvement of immune factors in OCD's pathophysiology.
  • Findings suggest potential avenues for immunotherapeutic interventions in OCD treatment.