Increased functional connectivity of the posterior cingulate cortex with the lateral orbitofrontal cortex in
Wei Cheng1, Edmund T Rolls2,3, Jiang Qiu4,5
1Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, 200433, China.
Translational Psychiatry
|April 26, 2018
Summary
This study reveals altered brain connectivity in depression, linking the posterior cingulate cortex (PCC) to non-reward pathways. Medication may normalize this connectivity, offering new therapeutic targets for depression.
Area of Science:
- Neuroimaging
- Psychiatry
- Cognitive Neuroscience
Background:
- Depression is associated with altered brain function.
- The posterior cingulate cortex (PCC) plays a role in mood regulation.
- Understanding PCC connectivity is crucial for depression research.
Purpose of the Study:
- To investigate the functional connectivity of the PCC in major depressive disorder (MDD).
- To explore the relationship between PCC connectivity and the lateral orbitofrontal cortex (lOFC) in depression.
- To assess the impact of medication on PCC connectivity.
Main Methods:
- Voxel-level resting-state functional connectivity neuroimaging analysis.
- Comparison of 336 patients with MDD and 350 healthy controls.
- Analysis of connectivity between PCC and other brain regions, including the lOFC and parahippocampal regions.
Main Results:
- Increased functional connectivity between PCC and lOFC in patients with MDD.
- Medication reduced the increased PCC-lOFC connectivity towards control levels.
- In controls, PCC showed high connectivity with memory-related parahippocampal regions.
Conclusions:
- The lOFC's non-reward system may influence memory systems in depression, contributing to rumination.
- Altered PCC connectivity is a key feature of depression.
- The lOFC presents a potential therapeutic target for ameliorating depression.
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