Related Experiment Video
Updated: Feb 11, 2026
07:44
Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction
Published on: March 25, 2022
6.8K
[Primary biliary cholangitis-established and novel therapies].
1Medizinische Klinik 1, Friedrich-Alexander-Universität Erlangen-Nürnberg, Ulmenweg 18, 91054, Erlangen, Deutschland.
Der Internist
|April 26, 2018
Summary
Primary biliary cholangitis (PBC) patients with poor treatment response need consistent management. New therapies like ursodeoxycholic acid (UDCA) and obeticholic acid (OCA) improve outcomes, making symptom management for fatigue and pruritus crucial.
Area of Science:
- Hepatology
- Gastroenterology
- Internal Medicine
Background:
- Primary biliary cholangitis (PBC) poses significant risks for disease progression and complications in patients with inadequate treatment response or risk factors.
- Extrahepatic manifestations of PBC can severely impair patients' quality of life.
Purpose of the Study:
- To provide an overview of standard ursodeoxycholic acid (UDCA) therapy and alternative treatment options for PBC patients.
- To present practical, symptom-oriented therapies for managing pruritus and fatigue in PBC.
Main Methods:
- Review of current European and German guidelines (2017).
- Inclusion of findings from research papers and expert opinions.
Main Results:
- Ursodeoxycholic acid (UDCA) is the recommended lifelong therapy for all PBC patients.
- Obeticholic acid (OCA) is approved as a second-line therapy for inadequate UDCA responders.
- Off-label options include fibrates and budesonide; colestyramine and rifampicin are recommended for pruritus; fatigue management involves excluding other causes and lifestyle adjustments.
Conclusions:
- Ursodeoxycholic acid (UDCA) and obeticholic acid (OCA) are effective, approved treatments for PBC.
- Consistent management is essential for PBC patients with risk factors or insufficient response.
- With improved cholestatic treatments, managing fatigue and pruritus is increasingly vital for PBC patients.
Related Concept Videos
00:59Gene Therapy
27.7K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
01:26Group Therapy
460
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
460
01:22Behavior Therapy
732
Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
732
01:28Drug Therapy
304
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
304
01:25Cognitive Therapy
1.3K
Cognitive therapy, pioneered by Aaron T. Beck in the 1960s, is a structured approach to addressing psychological distress by focusing on the influence of thoughts on emotions and behaviors. All cognitive therapies involve the basic assumption that human beings have control over their feelings, and that how individuals feel about something depends on how they think about it. Unlike psychoanalytic methods that delve into unconscious processes or humanistic approaches emphasizing...
1.3K
01:30Electroconvulsive Therapy
1.3K
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
1.3K