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Fluorescence detection methods for microfluidic droplet platforms
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Droplet Behavior in Open Biphasic Microfluidics.

Jing J Lee1, Jean Berthier1,2,3, Kenneth A Brakke4

  • 1Department of Chemistry , University of Washington , Box 351700 , Seattle , Washington 98195 , United States.

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|April 26, 2018
PubMed
Summary
This summary is machine-generated.

Spontaneous capillary flow (SCF) in open microchannels is demonstrated for two-phase systems. Immiscible plugs do not stop SCF, and their behavior is predictable, enabling new droplet-based microfluidic applications.

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Area of Science:

  • Biotechnology
  • Microfluidics
  • Fluid Dynamics

Background:

  • Open microfluidic systems offer advantages for fluid control in biotechnology and diagnostics.
  • Two-phase capillary flows in open systems are under-explored compared to closed systems.

Purpose of the Study:

  • To establish the theoretical basis and experimental evidence for spontaneous capillary flow (SCF) of two-phase systems in open microchannels.
  • To investigate the behavior of immiscible plugs within these flows.

Main Methods:

  • Theoretical analysis of capillary flow dynamics.
  • Numerical simulations to model plug morphologies.
  • Experimental validation of predicted plug behaviors.

Main Results:

  • Analytical results confirm that immiscible plugs cannot halt SCF in uniform open microchannels.
  • Numerical and experimental findings reveal three distinct plug behaviors influenced by inertial forces.
  • A predictive model for plug behavior in SCFs was developed.

Conclusions:

  • The study provides a foundational understanding of two-phase SCF in open microchannels.
  • The developed model facilitates the design of user-friendly, open microfluidic droplet-based systems.
  • This approach enables accessible, on-demand manipulation of individual droplets for diverse applications.