Related Experiment Video
Updated: Nov 12, 2025
05:57
Establishment and Histological Analysis of Esophageal Organoids Modeling the Progression from Normal to Cancerous Tissues
Published on: May 30, 2025
704
Organoids in cancer research
Jarno Drost1, Hans Clevers2,3,4
1Princess Máxima Centre for Paediatric Oncology, Utrecht, Netherlands. j.drost@prinsesmaximacentrum.nl.
Nature Reviews. Cancer
|April 26, 2018
Summary
Organoids, advanced 3D human cancer models, offer physiological preclinical research platforms. These models facilitate patient-specific drug testing and personalized cancer treatment development.
Area of Science:
- Biomedical Engineering
- Cancer Research
- Stem Cell Biology
Background:
- In vitro 3D culture technologies, including organoids, are advancing cancer modeling.
- Organoids mimic physiological conditions, improving preclinical research translation.
- Patient-derived organoids enable personalized medicine approaches.
Purpose of the Study:
- To review tumor organoid protocols for cancer research.
- To highlight organoids as alternative models for studying cancer.
- To discuss the potential of organoids in developing novel cancer treatments.
Main Methods:
- Review of existing literature on tumor organoid protocols.
- Evaluation of organoid self-organizing capacities and genetic modification.
- Assessment of organoid derivation from patient tissues.
Main Results:
- Organoids provide a more physiological in vitro human cancer model.
- Genetically modified organoids enable accurate disease modeling.
- High-efficiency derivation from patient tissues supports personalized drug testing.
Conclusions:
- Tumor organoids represent a significant advancement in cancer research models.
- Organoid technology facilitates the development of individualized cancer therapies.
- Further evaluation of organoid protocols can optimize their use in preclinical settings.
