Inulin Improves Postprandial Hypertriglyceridemia by Modulating Gene Expression in the Small Intestine

Area of Science:

• Metabolic disorders
• Obesity research
• Nutritional science

Background:

• Postprandial hyperlipidemia is a key risk factor for cardiovascular diseases, especially in obesity.
• Inulin, a non-digestible carbohydrate, shows promise for managing metabolic disorders.

Purpose of the Study:

• To investigate the effects of inulin on postprandial hypertriglyceridemia and lipid metabolism in diet-induced obese mice.

Main Methods:

• Mice were fed a control or western diet, supplemented with inulin (0.2 g/day).
• Evaluated lipid tolerance, gene expression (Cd36, Apoc3), lipoprotein lipase activity, enterocyte lipid accumulation, and fecal lipid excretion.

Main Results:

• Inulin reduced postprandial serum triglycerides in obese mice.
• Decreased jejunal expression of Cd36 and Apoc3.
• Increased fecal lipid excretion.

Conclusions:

• Inulin improves postprandial hypertriglyceridemia by targeting intestinal lipid metabolism.
• Supports inulin supplementation for managing obesity-related dyslipidemia and cardiometabolic risk.