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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Blind Procedures02:07

Blind Procedures

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Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
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Handwashing II: Pre-procedure and Initial Procedure Steps01:19

Handwashing II: Pre-procedure and Initial Procedure Steps

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The pre-procedure steps of handwashing include removing jewelry and rolling up sleeves. However, many organizations allow staff to wear wedding rings.
The hand washing procedure itself includes the following steps. First, cover cuts, if any, on hands with a waterproof dressing. Cuts and abrasions can become contaminated with bacteria hindering the ability to clean the area thoroughly. In addition, repeated hand washing can worsen an injury.  The nails must be short and clean, without nail...
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Handwashing III: During the Procedure and Post-Procedure Steps01:15

Handwashing III: During the Procedure and Post-Procedure Steps

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To wash hands properly, follow these steps:
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Related Experiment Video

Updated: Feb 11, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
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Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

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Cyclodestructive procedures for non-refractory glaucoma.

Manuele Michelessi1, Amanda K Bicket, Kristina Lindsley

  • 1Ophthalmology, Fondazione G.B. Bietti per lo studio e la ricerca in Oftalmolologia-IRCCS, Via Livenza n 3, Rome, Italy, 00198.

The Cochrane Database of Systematic Reviews
|April 26, 2018
PubMed
Summary
This summary is machine-generated.

Cyclodestructive procedures show limited evidence for effectively managing non-refractory glaucoma. More research is needed to compare laser cyclophotocoagulation energy levels and safety.

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Related Experiment Videos

Last Updated: Feb 11, 2026

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Area of Science:

  • Ophthalmology
  • Glaucoma Management
  • Surgical Interventions

Background:

  • Glaucoma is a leading cause of irreversible blindness globally, characterized by progressive vision loss.
  • Elevated intraocular pressure (IOP) is a primary modifiable risk factor for glaucoma.
  • Cyclodestructive procedures, particularly laser cyclophotocoagulation, aim to reduce IOP by decreasing aqueous humor production.

Purpose of the Study:

  • To evaluate the effectiveness and safety of cyclodestructive procedures for non-refractory glaucoma.
  • To compare different laser cyclophotocoagulation parameters, including energy levels and delivery methods.
  • To assess outcomes such as IOP control, visual acuity, pain, and adverse events.

Main Methods:

  • Systematic search of multiple databases including CENTRAL, MEDLINE, Embase, LILACS, mRCT, and ClinicalTrials.gov.
  • Inclusion of randomized controlled trials comparing cyclophotocoagulation as a primary treatment.
  • Independent screening, data extraction, and risk of bias assessment by two reviewers.

Main Results:

  • One trial (92 participants) evaluated diode transscleral cyclophotocoagulation (TSCPC) comparing low-energy versus high-energy settings.
  • IOP control (≥20% decrease) was achieved in 47% of eyes, with no significant difference between energy levels (low-certainty evidence).
  • Vision decrease occurred in 23% of eyes; differences between energy settings were uncertain. Moderate-certainty evidence showed similar medication use. Adverse events included pain, conjunctival burns, iritis, and hyphema.

Conclusions:

  • Insufficient evidence exists to determine the effectiveness and safety of cyclodestructive procedures for primary non-refractory glaucoma management.
  • The single included trial provided uncertain results regarding low-energy versus high-energy TSCPC, with modest IOP control and limited vision loss.
  • Further high-quality research is necessary to guide treatment decisions for non-refractory glaucoma using cyclodestructive interventions.