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Emina Emilia Torlakovic1,2

  • 1Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, and Saskatchewan Health Authority, Saskatoon, Canada. emina.torlakovic@usask.ca.

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|April 27, 2018
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Summary
This summary is machine-generated.

Practicing pathologists need to understand immunohistochemistry (IHC) biomarker panels and quality assurance (QA) for accurate diagnostic testing. Collaborative efforts between pathologists and technologists ensure IHC tests are fit-for-purpose, especially in endocrine pathology.

Keywords:
BiomarkersImmunohistochemistryQuality assuranceValidation

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Area of Science:

  • Pathology
  • Laboratory Medicine
  • Biomarker Development

Background:

  • Immunohistochemistry (IHC) is crucial for diagnostic, prognostic, and predictive testing in pathology.
  • Effective IHC requires understanding both biomarker panels and robust quality assurance (QA).
  • Current IHC QA concepts are vital for practicing pathologists, particularly in specialized fields like endocrine pathology.

Purpose of the Study:

  • To review current IHC quality assurance (QA) concepts relevant to practicing pathologists.
  • To highlight the importance of understanding IHC biomarker panels for clinical applications.
  • To emphasize the collaborative approach needed between pathologists and laboratory technologists for "fit-for-purpose" IHC biomarkers.

Main Methods:

  • Review of current literature and best practices in immunohistochemistry.
  • Focus on quality assurance principles and their application in pathology.
  • Emphasis on challenges specific to endocrine pathology.

Main Results:

  • Two key aspects for pathologists: IHC biomarker panel selection and IHC quality assurance (QA).
  • IHC QA ensures the reliability and accuracy of diagnostic, prognostic, and predictive tests.
  • A collaborative approach is essential for developing and maintaining "fit-for-purpose" IHC biomarkers.

Conclusions:

  • Understanding IHC biomarker panels and QA is critical for practicing pathologists.
  • Effective QA is fundamental to the reliable performance of IHC tests.
  • Collaboration between pathologists and technologists is key to advancing IHC applications, especially in endocrine pathology.