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Fit-for-Purpose Immunohistochemical Biomarkers
1Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, and Saskatchewan Health Authority, Saskatoon, Canada. emina.torlakovic@usask.ca.
Endocrine Pathology
|April 27, 2018
Summary
Practicing pathologists need to understand immunohistochemistry (IHC) biomarker panels and quality assurance (QA) for accurate diagnostic testing. Collaborative efforts between pathologists and technologists ensure IHC tests are fit-for-purpose, especially in endocrine pathology.
Area of Science:
- Pathology
- Laboratory Medicine
- Biomarker Development
Background:
- Immunohistochemistry (IHC) is crucial for diagnostic, prognostic, and predictive testing in pathology.
- Effective IHC requires understanding both biomarker panels and robust quality assurance (QA).
- Current IHC QA concepts are vital for practicing pathologists, particularly in specialized fields like endocrine pathology.
Purpose of the Study:
- To review current IHC quality assurance (QA) concepts relevant to practicing pathologists.
- To highlight the importance of understanding IHC biomarker panels for clinical applications.
- To emphasize the collaborative approach needed between pathologists and laboratory technologists for "fit-for-purpose" IHC biomarkers.
Main Methods:
- Review of current literature and best practices in immunohistochemistry.
- Focus on quality assurance principles and their application in pathology.
- Emphasis on challenges specific to endocrine pathology.
Main Results:
- Two key aspects for pathologists: IHC biomarker panel selection and IHC quality assurance (QA).
- IHC QA ensures the reliability and accuracy of diagnostic, prognostic, and predictive tests.
- A collaborative approach is essential for developing and maintaining "fit-for-purpose" IHC biomarkers.
Conclusions:
- Understanding IHC biomarker panels and QA is critical for practicing pathologists.
- Effective QA is fundamental to the reliable performance of IHC tests.
- Collaboration between pathologists and technologists is key to advancing IHC applications, especially in endocrine pathology.
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