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A time for YAP1: Tumorigenesis, immunosuppression and targeted therapy
Masahiro Shibata1, Kendall Ham1, Mohammad Obaidul Hoque1
1Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
International Journal of Cancer
|April 27, 2018
Summary
The Yes-associated protein 1 (YAP1) pathway drives cancer growth and immune suppression. Inhibiting YAP1 may enhance cancer therapies and overcome drug resistance by modulating the tumor microenvironment.
Area of Science:
- Oncology
- Molecular Biology
- Immunology
Background:
- The Hippo pathway effector YAP1 promotes cancer progression, stem cell expansion, and drug resistance.
- Immunotherapy, including immune checkpoint blockade, is effective against various cancers.
- Tumor microenvironment (TME) immunosuppression hinders anti-cancer immunity and treatment efficacy.
Purpose of the Study:
- To review the dual roles of YAP1 in cancer development and TME immunosuppression.
- To explore YAP1 as a potential therapeutic target in oncology.
Main Methods:
- Literature review of recent studies on YAP1, cancer, and the immune microenvironment.
- Analysis of evidence linking YAP1 pathways to immunosuppressive cell populations within the TME.
Main Results:
- YAP1 signaling contributes to malignant phenotypes and cancer stem cell populations.
- YAP1 influences immune cells like macrophages, myeloid-derived suppressor cells, and regulatory T-cells to create an immunosuppressive TME.
- Evidence suggests YAP1 activation pathways promote tumor progression and drug resistance.
Conclusions:
- YAP1 plays a significant role in both cancer progression and the establishment of an immunosuppressive TME.
- Targeting YAP1 presents a promising therapeutic strategy to enhance anti-cancer immunity and overcome treatment resistance.
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