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Atrial natriuretic factor release is enhanced by incremental atrial pacing
K A Ellenbogen1, P K Mohanty, J R Sowers
1Department of Medicine, Medical College of Virginia, Richmond, VA.
American Heart Journal
|August 1, 1988
Summary
Increased atrial pacing in humans stimulates atrial natriuretic factor (ANF) secretion, along with rising atrial pressure and size. These findings confirm animal model data in a human clinical setting, advancing understanding of ANF regulation.
Area of Science:
- Cardiology
- Endocrinology
- Physiology
Background:
- Animal models suggest atrial natriuretic factor (ANF) secretion is triggered by increased atrial contraction frequency or distension.
- The precise human response to these stimulatory signals remains incompletely understood.
Purpose of the Study:
- To investigate the effects of graded right atrial pacing on atrial pressure, left atrial size, and plasma ANF levels in humans.
Main Methods:
- Twenty-eight patients underwent right atrial pacing at 100, 125, and 150 beats/min.
- Measurements included right atrial pressure, left atrial size (echocardiography), and plasma ANF levels.
- Baseline and post-pacing values were compared.
Main Results:
- Pacing at 125 and 150 beats/min significantly increased plasma ANF levels (p<0.05 and p<0.001, respectively).
- Right atrial pressure and left atrial dimension also increased significantly at 125 and 150 beats/min (p<0.05 and p<0.001).
- No significant changes were observed at 100 beats/min.
Conclusions:
- Increased atrial pacing in humans effectively stimulates ANF secretion.
- The findings correlate with animal studies, demonstrating a direct relationship between atrial activity/pressure and ANF release in humans.