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Updated: Feb 11, 2026

Author Spotlight: A 3D Digital Model for the Diagnosis and Treatment of Pulmonary Nodules
Published on: May 19, 2023
Case report: Giant cystic lesions with a rare pulmonary diagnosis
Ruth Siew1,2, Eulalia R Y Cheng1,2
1Division of Respiratory Medicine, Department of Pediatrics, UC San Diego, La Jolla, California.
Abstract:
A 14-year-old male who presented with back pain was found to have giant cystic lesions on CXR and emphysematous changes on chest CT. He underwent right lobectomies and histopathology of the resected lesions demonstrated giant bullous emphysema with placental transmogrification. This has not been previously described in a pediatric patient. We describe his clinical findings, pulmonary function tests, and post-operative course. The pathogenesis of placental transmogrification remains uncertain. As this is the first reported pediatric case, we propose that giant bullous emphysema with placental transmogrification should be considered in the differential diagnosis for cystic lesions in the pediatric age group.
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