Twofold CuZnSOD activity suggesting homozygous submicroscopic duplication of chromosome 21 in the orangutan
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J de Grouchy1, A Nicole, C Cochet
1U 173 INSERM, Hôpital Necker-Enfants Malades, Paris.
Annales De Genetique
|January 1, 1988
Abstract:
A twofold CuZnSOD activity was observed in an orangutan as compared to man and a chimpanzee. This suggests that a submicroscopic duplication of chromosome 21 (similar to those demonstrated in patients with the trisomy 21 phenotype but with a normal karyotype) has occurred in the homozygous state during evolution of the orangutan phylum. Such duplications could be important evolutionary mechanisms, together with visible chromosome rearrangements and classical gene mutations.