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Published on: December 18, 2016
Impact of pathological features of brain metastases in prognosis
Carlos A Castaneda1,2, Miluska Castillo3, Luis A Bernabe3
1Department of Medical Oncology, Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru.
Aim:
To evaluate the prognostic value of tumor-infiltrating lymphocytes (TILs) and Ki67 in brain metastasis lesions, and the effect of adding them to variables of graded prognostic assessment score.
Patients & Methods:
Clinicopathological information from 111 medical charts of brain metastasis patients was obtained, and TIL distribution (n = 84), Ki67 index (n = 79) and CD3 TIL (n = 64) were prospectively evaluated.
Results:
Most frequent TIL pattern was perivascular (67.8%), and median Ki67 and CD3 TIL percents were 30 and 4.8%, respectively. Ki67 ≥15 was associated with shorter survival (p = 0.018) but CD3 TIL was not (p = 0.870). The highest graded prognostic assessment score was not associated with survival (p = 0.648), however, those with low Ki67 and high score was associated with better outcome (p = 0.007).
Conclusion:
High Ki67 index in brain metastasis carries a worse prognosis.
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