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Updated: Feb 11, 2026
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Corneal Donor Tissue Preparation for Endothelial Keratoplasty
Published on: June 12, 2012
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Graft Failure and Repeat Penetrating Keratoplasty
Ozlem Barut Selver1, Irmak Karaca, Melis Palamar
1From the Department of Ophthalmology, Ege University, Izmir, Turkey.
Summary
Repeat penetrating keratoplasty (PKP) outcomes were analyzed. Bullous keratopathy and corneal dystrophy were primary indications, while endothelial failure and allograft rejection were key reasons for graft failure in repeat PKP.
Area of Science:
- Ophthalmology
- Corneal Surgery
- Transplantation
Background:
- Graft failure is a significant concern in penetrating keratoplasty (PKP).
- Understanding reasons for repeat PKP and graft failure is crucial for improving outcomes.
Purpose of the Study:
- To report indications and outcomes of repeat penetrating keratoplasty.
- To identify common reasons for graft failure in repeat PKP.
Main Methods:
- Retrospective data analysis of patients undergoing 2 or more PKPs between 1991 and 2016.
- Review of 149 regrafts from 105 eyes.
Main Results:
- Bullous keratopathy (31.4%) and corneal dystrophy (20.0%) were primary indications for repeat PKP.
- Endothelial failure (55.7% combined) and allograft rejection (17.4%) were leading causes of graft failure.
- 59% of repeat PKPs had clear grafts at last follow-up, with a mean best-corrected visual acuity of 1.26 logMAR.
Conclusions:
- Primary indications and reasons for graft failure significantly impact long-term outcomes.
- Identifying risk factors and causes of failure can guide preventive strategies for repeat PKP.
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